Profhilo vs rejuran vs skinboosters vs nucleofill | 逆时针🆚婴儿针🆚水光针 |Korean Aesthetic Academy

In the past, i stuck strictly to Rejuran. I was awaiting more evidence and I like to stick to tried and tested, time honoured products. Now, I have to say, I think Profhilo is really really badass good.

What is profhilo? 逆时针

It is a new technology that biologically remodels your skin.
Neither a filler nor skin booster, Profhilo® is a patented technology of bio-remodeling injectable.
In my clinical experience,

In my clinical experience, I find that Skinboosters 水光针| Hydroboosters | Babyboosters are perfect for hydrating our skin. We need a series of 3 – 4 sessions. Cost is cheapest.

Rejuran 婴儿针, via PDRN technology, helps renew your skin and is perfect for skin remodelling, hence pore tightening and improving skin laxity. We need a series of 3 – 4 sessions.

The key benefit of Profhilo, is its ability to remodel skin and improve skin laxity. We need a series of 2 sessions minimum, and cost is an issue. But in experienced hands and at reasonable price, do the results justify the cost? Lets investigate. 

How does Profhilo work?

Profhilo® can bio-stimulate
4 types of collagen | elastin | proliferate adipocytes (fat) stem cells

How quickly does Profhilo work?

You will start seeing results 4 weeks after 1st treatment. Best results in 8 weeks after 1st session. 

Why is Profhilo so popular?

As you grow older, your skin’s hyaluronic acid levels dip. Hyaluronic acid is one of the things that keep skin looking plumped up and hydrated,

There are a number of brands of injectable moisturiser out there, but Profhilo is the one that has caught people’s imagination. It’s not a filler, it doesn’t add volume to the face, but it improves the skin health and strength.

BONUS: Profhilo requires far fewer injections than some other products, so less pain, less downtime, less bruising.

Profhilo works from the inside, boosting hydration and encouraging bioremodelling of your collagen and elastin fibres.

Older skin is characterised by loss of and abnormalities in Hyaluronic acid, collagen and elastin.

In this way, Profhilo is designed to improve the levels and quality of the three biological factors, keeping your skin looking fresh, plump and youthful

Is Profhilo better than a filler?

Profhilo is not a dermal filler. It works by remodelling skin, so its more than your typical skinbooster. It has anti-ageing and skin firming properties. Works very naturally and skin quality changes are visible in majority of cases.

Is Profhilo dangerous?

Profhilo is FDA approved for anti ageing. In some cases, you may experience side effects are redness, soreness and bruising. 

How does skin remodelling help you?

According to the manufacturer, this technology can

  1. Reverse ageing
  2. combat skin laxity and signs of skin aging
  3. boost and hydrate your skin

Is Profhilo safe on human skin?

It is a 100% pure hyaluronic acid compound, completely biocompatible with skin, so it doesn’t harm skin tissue in any way. According to the manufacturer: During clinical testing, Profhilo® showed no negative side-effects.

Is there any pain or downtime in the treatment?

With just 5 injections per side, the downtime is minimal, with less pain, less swelling, less bruising.
The Hyaluronic Acid diffuses across the widest sections of your face through subdermal patterns, stimulating the production of elastin, collagen and hydration in the skin.

How many sessions would I need?

In majority of cases, at least 2 sessions*, spaced 1 month apart, Profhilo® can last between 6 – 12 months.

How often would I need Profhilo?

The current recommendation is yearly.

Please don’t drink any alcohol during the 24 hours before your treatment. We also advise that you avoid using aspirin or other non-steroidal anti-inflammatory drugs a couple of days before your treatment (unless they are taken for a chronic medical condition) to reduce the risk of bruising.

The downtime following a Profhilo®️ treatment is minimal. There will be small localised bumps where the product is placed. This is not cause for concern and is a normal process. These bumps will then start to diffuse very quickly, majority within 1 – 3 days. In very rare instances, up to 3 weeks.

You may notice a refreshed appearance even a week after your treatment, however, the full results can be seen 4 weeks after your second treatment.

You can have Profhilo treatment and continue with your day to day activities. However, we do advise that you avoid wearing makeup, or touching your face after treatment to reduce infection risk.

After the treatment, it is recommended to avoid physical strain and sports for 24 hours. Please also avoid having further cosmetic procedures for 48 hours. It is not recommended to have sauna or steamy bath for the first few days either. It’s best to stay out of the sun if any bruising or prolonged swelling occurs.

Can Profhilo be combined with other products?

Profhilo® delivers great results as a treatment on its own or in combination with other aesthetics treatments. And yes, I like to combine it to give my patients optimum results with minimal pain and downtime.

What is nucleofill and how does it help aging?

Its main indication is the treatment of facial aging as it reverses the effects of skin laxity associated
with age.
It has the following effects:
✓ Bioremodelation: with the concentration of Nucleofill 2% we have the possibility of
intervening on skin laxity.
✓ Bioregenerating the dermis and stimulating the synthesis of collagen and elastin. This will
stimulate the fibroblast and achieve a neoformation of the dermal matrix, as well as a
restructuring thereof – thanks to the formation of type I collagen.
✓ Hydrolifting: hydrating and stimulating the production of endogenous hyaluronic acid.
✓ Support in the mechanical remodeling of the dermis.

Nucleofill has beneficial properties at different levels:
✓ Increased synthesis of collagen in keratinocytes;
✓ Increase in elastin synthesis (by fibroblasts and keratinocytes);
✓ Increase in fibroblast synthesis;
✓ Feeding of the dermis cells;
✓ Improvement of the elasticity of the skin;
✓ Less inflammatory response;
✓ Prolonged action over time.

Conclusion: Is Profhilo better than Rejuran and nucleofill?

Safety wise, it is FDA approved.

Efficacy wise, there are clinical papers supporting it, but pretty low powered papers.

Price wise, it is way more expensive. Rejuran is at $799 per 2ML syringe, Skinboosters at $699 per 1ML, Profhilo starts from 1k per 2ml. Nucleofill starts @800 per syringe.

Previously, I mentioned I will be sticking to rejuran for now, until better studies are out. I have had very good experience with Rejuran for skin tone and textural improvement and as the saying goes, if it aint broken, dont fix it. || Now I say, Profhilo is bad-ass good. And I will recommend it for certain groups of patients, together with Nucleofill for optimum results ✅
– Dr Daniel Chang

Daniel Chang
Dr Daniel Chang


1) Stellavato A. et al. 2016; PLoS One 11(10):e0163510. 

2) Stellavato A. et al. 2017 Cell Physiol Biochem 2017; 44:1078-1092. 

3) Profhilo leaflet. 

4) D’Agostino A. et al. 2015; BMC Cell Biol 16:19. 

5) Sundaram H. et al. 2016;  Poster Presentation, American Society for Dermatologic Surgery (ASDS) Annual Meeting. 

6) Sparavigna A. et al. 2016; Clin Cosmet Investig Dermatol 9:297-305. 

7) Laurino C. et al. 2015; Eplasty 15:e46. 

8) Rodríguez Abascal M et al. 2015; Eur Aesth Plast Surg J 2015; 5(2): 124-131. 

9) Beatini A. et al. 2016; Aesthetic Medicine 2(2):45-51  


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