Profhilo vs Volite vs Rejuran skinboosters vs Nucleofill Guide

1. What is Juvederm Volite skinbooster?

1.1 What is a Volite skinbooster?

Volite is an innovative injectable treatment designed to improve skin quality for up to 9 months. Its an injectable skin moisturiser, a top grade skin conditioning Hyaluronic acid (HA) gel. Volite is injected into the middle layers of the dermis across many sites to nourish it from the inside out.

1.2 Does Volite skinboosters add volume?

Juvederm Volite skinbooster can be used as a dermal filler. It can be used to add volume and remodelling or Juvederm Volite can be used as a stand alone treatment especially good for our younger patients or if you simply want glowing skin. I find it useful for fine lines for example, skin lines, esp when used together with microbotox. Below is an example.

1.3 How effective is Volite skinboosters?

As mentioned, Volite delivers improvements in skin quality including smoothness (absence of fine lines), hydration and elasticity. In clinical studies, results were sustained at six months, where patients reported that they continued to see significant improvements in skin hydration and were satisfied with their skin.

I find the glow and skin hydration from Juvederm Volite improvement superior to majority of skinboosters in the market. I also find the duration superior.

In the past, i stuck strictly to Rejuran Healer PDRN. I was awaiting more evidence and I like to stick to tried and tested, time honoured products. I have to say, I think Profhilo is really badass good. Now, theres Nucleofill PDRN, a higher molecular weight PDRN that has a role to contribute in skin rejuvenation. And with Juvederm Volite, we have a skinbooster treatment that lasts 9 months.

2. What is profhilo? | 逆时针

It is a new technology that biologically remodels your skin.
Neither a filler nor skin booster, Profhilo® is a patented technology of bio-remodeling injectable.

In my clinical experience, I find that Skinboosters 水光针| Hydroboosters | Babyboosters are perfect for hydrating our skin. We need a series of 3 – 4 sessions. Cost is cheapest. Product consists of hyluronic acid, compatible with your skin.

Nucleofill, Rejuran 婴儿针, via PDRN technology, helps renew your skin and is perfect for skin remodelling, hence pore tightening and improving skin laxity. We need a series of 3 – 4 sessions.

The key benefit of Profhilo, is its ability to remodel skin and improve skin laxity. We need a series of 2 sessions minimum, and cost is an issue. But in experienced hands and at reasonable price, do the results justify the cost? Lets investigate. 

What does Profhilo do for your face?

It stimulates collagen and elastin, which are key ingredients for face rejuvenation and anti-ageing.

How long do the results of Profhilo last?

2 sessions can last 6 months.

What are the negative side-effects of Profhilo?

Bruising and swelling in skin.

Does Profhilo change your face shape?

It is not a dermal filler, hence it does not change your face shape.

Which is better Botox or Profhilo?

Botox is great for wrinkle reduction in upper face. Profhilo is FDA approved for mid to lower face.

Why do you need 2 sessions of Profhilo?

2.1 How does Profhilo work?

Is Profhilo better than Botox?

The 2 are complementary. Botox works to reduce dynamic lines. Profhilo improves overall skin complexion and helps with static lines.

Profhilo® can bio-stimulate
4 types of collagen | elastin | proliferate adipocytes (fat) stem cells

How long does Profhilo last?

Profhilo generally lasts 6 months if 2 treatments are given one month apart. After the initial treatments, we recommend coming back to see us every 6-9 months. Then only one syringe is needed, as we will be simply topping up the skin’s hydration and glow.

Is Profhilo worth doing?

Given its price tag, is it really worth it, though? The simple answer is, yes it is. It is quick, effective, less painful with 5 point injection, and does not carry the same risks as other procedures. It provides you with young, healthy, glowy, dewey, fresher looking skin.

Is Profhilo dangerous? How many sessions of Profhilo would I need?

In majority of cases, at least 2 sessions*, spaced 1 month apart, Profhilo® can last between 6 – 12 months.

Profhilo is FDA approved for anti ageing. In some cases, you may experience side effects are redness, soreness and bruising. 

Is Profhilo safe on human skin?

It is a 100% pure hyaluronic acid compound, completely biocompatible with skin, so it doesn’t harm skin tissue in any way. According to the manufacturer: During clinical testing, Profhilo® showed no negative side-effects.

How quickly does Profhilo work?

You will start seeing results 4 weeks after 1st treatment. Best results in 8 weeks after 1st session.

Why is Profhilo so popular?

As you grow older, your skin’s hyaluronic acid levels dip. Hyaluronic acid is one of the things that keep skin looking plumped up and hydrated,

There are a number of brands of injectable moisturiser out there, but Profhilo is the one that has caught people’s imagination. It’s not a filler, it doesn’t add volume to the face, but it improves the skin health and strength.

BONUS: Profhilo requires far fewer injections than some other products, so less pain, less downtime, less bruising.

Profhilo works from the inside, boosting hydration and encouraging bioremodelling of your collagen and elastin fibres.

Older skin is characterised by loss of and abnormalities in Hyaluronic acid, collagen and elastin.

In this way, Profhilo is designed to improve the levels and quality of the three biological factors, keeping your skin looking fresh, plump and youthful
Is Profhilo better than a filler?

Profhilo is not a dermal filler. It works by remodelling skin, so its more than your typical skinbooster. It has anti-ageing and skin firming properties. Works very naturally and skin quality changes are visible in majority of cases.

Is there any pain or downtime in the treatment?

With just 5 injections per side, the downtime is minimal, with less pain, less swelling, less bruising.
The Hyaluronic Acid diffuses across the widest sections of your face through subdermal patterns, stimulating the production of elastin, collagen and hydration in the skin.

How does skin remodelling help you?

According to the manufacturer, this technology can

  1. Reverse ageing
  2. combat skin laxity and signs of skin aging
  3. boost and hydrate your skin

2.2 How often would I need Profhilo?

The current recommendation is yearly.

Please don’t drink any alcohol during the 24 hours before your treatment. We also advise that you avoid using aspirin or other non-steroidal anti-inflammatory drugs a couple of days before your treatment (unless they are taken for a chronic medical condition) to reduce the risk of bruising.

The downtime following a Profhilo®️ treatment is minimal. There will be small localised bumps where the product is placed. This is not cause for concern and is a normal process. These bumps will then start to diffuse very quickly, majority within 1 – 3 days. In very rare instances, up to 3 weeks.

You may notice a refreshed appearance even a week after your treatment, however, the full results can be seen 4 weeks after your second treatment.

You can have Profhilo treatment and continue with your day to day activities. However, we do advise that you avoid wearing makeup, or touching your face after treatment to reduce infection risk.

After the treatment, it is recommended to avoid physical strain and sports for 24 hours. Please also avoid having further cosmetic procedures for 48 hours. It is not recommended to have sauna or steamy bath for the first few days either. It’s best to stay out of the sun if any bruising or prolonged swelling occurs.

Can Profhilo be combined with other products?

Profhilo® delivers great results as a treatment on its own or in combination with other aesthetics treatments. And yes, I like to combine it to give my patients optimum results with minimal pain and downtime.

3. What is Nucleofill?

Nucleofill is a relatively new bio-stimulator for skin rejuvenation and protection. As an anti-ageing treatment, it is designed to help cells retain water, improve skin elasticity and tightness, and aid in the prevention of wrinkles.

3.1 Nucleofill vs Profhilo | Which is right for you? Is Nucleofill a filler?

Nucleofill is strictly not a filler. It consists of high molecular weight PDRN, derived from Salmon DNA. This treatment is safe on all skin types. This treatment can be done in combination with other treatments.

3.2 So what is Rejuran healer treatment?

What is PDRN treatment? What is nucleofill skin treatment?

This is the use of highly bio-compatible DNA fragments (Polynucleotides), derived from Salmon DNA, to improve the overall condition of your skin. It helps to repair skin, reduce inflammation and reduce ischemia.

3.3 Are the effects of Rejuran healer, PDRN, nucleofill permanent?

Is Rejuran, Nucleofill permanent?

Collagen-stimulating treatments such as rejuran, nucleofill, sculptra are effective for rolling scars. They produce semi-permanent effects. The result of these new collagen stimulated lasts in line with your skin’s natural ageing.

How long can Rejuran Healer, Nucleofill last?

The duration depends on many factors, such patient, physician and product factors. Examples include physician technique, individual skin condition, choice of filler product, area treated. In expert hands, the effects typically lasts between 6-12 months.

 Moving on, we will dive deep into the evidence for PDRN, rejuran, nucleofill.

  1. Literature
  2. Indications
  3. Technique
Squadrito, Francesco & Bitto, Alessandra & Irrera, Natasha & Pizzino, Gabriele & Pallio, Giovanni & Minutoli, Letteria & Altavilla, Domenica. (2017). Pharmacological Activity and Clinical Use of PDRN. Frontiers in Pharmacology. 8. 10.3389/fphar.2017.00224.
  1. This is an Italian study, and is the country of origin for Nucleofill.      
  2. PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory.
  3. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers.
Shin, D.Y., Park, JU., Choi, MH. et al. Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing. Sci Rep 10, 16811 (2020).
  1. This is a Korean study, the origin of Rejuran healer.
  2. These results suggest that incorporating PDRN within a hydrogel carrier can be used to achieve sustained delivery of the DNA with stimulatory biological effects while eliminating the use of needles, indicating the great potential for its use in non-invasive diabetic wound healing.
Lee SH, Zheng Z, Kang JS, Kim DY, Oh SH, Cho SB. Therapeutic efficacy of autologous platelet-rich plasma and polydeoxyribonucleotide on female pattern hair loss. Wound Repair Regen. 2015 Jan-Feb;23(1):30-6. doi: 10.1111/wrr.12250. Epub 2015 Feb 13. PMID: 25524027.
  1. This is another Korean study, comparing PDRN with PRP, a proven hair loss treatment for female pattern hair loss.
  2. In conclusion, intra-perifollicular injections of autologous PRP and/or PDRN generate improvements in hair thickness and density in FPHL patients.


3.4 What can PDRN, Rejuran healer, nucleofill help with?

  • Rejuvenation of midface
  • Rejuvenation of full face
  • Rejuvenation of Neck lines
  • Atrophic scars | acne scars | Inflammatory acne
  • Dark eye circle, Undereye rejuvenation |


Full face


Inflammatory acne

Acne scars

3.5 What is nucleofill and how does it help aging?

  • Its main indication is the treatment of facial aging as it reverses the effects of skin laxity associated with age.
  • ✓ Bioremodelation: with the concentration of Nucleofill 2% we have the possibility of
  • intervening on skin laxity.
  • ✓ Bioregenerating the dermis and stimulating the synthesis of collagen and elastin. This will
  • stimulate the fibroblast and achieve a neoformation of the dermal matrix, as well as a
  • restructuring thereof – thanks to the formation of type I collagen.
  • ✓ Hydrolifting: hydrating and stimulating the production of endogenous hyaluronic acid.
  • ✓ Support in the mechanical remodeling of the dermis.
  • Nucleofill has beneficial properties at different levels:
  • ✓ Increased synthesis of collagen in keratinocytes;
  • ✓ Increase in elastin synthesis (by fibroblasts and keratinocytes);
  • ✓ Increase in fibroblast synthesis;
  • ✓ Feeding of the dermis cells;
  • ✓ Improvement of the elasticity of the skin;
  • ✓ Less inflammatory response;
  • ✓ Prolonged action over time.

Conclusion: Is Profhilo better than Rejuran and nucleofill?

Safety wise, it is FDA approved.

Efficacy wise, there are clinical papers supporting it, but pretty low powered papers. I would say all have value in your skin rejuvenation journey.

Price wise, it is way more expensive. Rejuran is at $799 per 2ML syringe, Skinboosters at $699 per 1ML, Profhilo starts from 1k per 2ml. Nucleofill starts @800 per syringe.

Previously, I mentioned I will be sticking to rejuran for now, until better studies are out. I have had very good experience with Rejuran for skin tone and textural improvement and as the saying goes, if it aint broken, dont fix it. || Now I say, Profhilo is bad-ass good. And I will recommend it for certain groups of patients, together with Nucleofill for optimum results ✅”

– Dr Daniel Chang

Dr Daniel Chang


1) Stellavato A. et al. 2016; PLoS One 11(10):e0163510. 

2) Stellavato A. et al. 2017 Cell Physiol Biochem 2017; 44:1078-1092. 

3) Profhilo leaflet. 

4) D’Agostino A. et al. 2015; BMC Cell Biol 16:19. 

5) Sundaram H. et al. 2016;  Poster Presentation, American Society for Dermatologic Surgery (ASDS) Annual Meeting. 

6) Sparavigna A. et al. 2016; Clin Cosmet Investig Dermatol 9:297-305. 

7) Laurino C. et al. 2015; Eplasty 15:e46. 

8) Rodríguez Abascal M et al. 2015; Eur Aesth Plast Surg J 2015; 5(2): 124-131. 

9) Beatini A. et al. 2016; Aesthetic Medicine 2(2):45-51  

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