Nucleofill vs Profhilo vs Volite vs Rejuran skinboosters Guide

As the latest concept in biostimulation, Nucleofill is a polynucleotide-based injectable gel specifically designed to repair dull and tired skin.

What is Nucleofill treatment?

It consists of patented highly concentrated polynucleotide or PDRN.

Is Nucleofill strong a filler?

It is not regarded as a skin filler. It is a skin healer.

How long does Nucleofill strong last?

Whats the difference between Nucleofill and Profhilo?

The difference lies in the ingredient. Nucleofill contains PDRN for skin repair, while Profhilo contains Hyaluronic acid for skin hydration.

What are the effects of Nucleofill?

Thru a process of collagenesis, it is hydrating, tightening and firming.

How much does Nucleofill cost in Singapore?

From $599 onwards.

What is Juvederm Volite skinbooster?

What is a Volite skinbooster?

Volite is an innovative injectable treatment designed to improve skin quality for up to 9 months. Its an injectable skin moisturiser, a top grade skin conditioning Hyaluronic acid (HA) gel. Volite is injected into the middle layers of the dermis across many sites to nourish it from the inside out.

Does Volite skinboosters add volume?

Juvederm Volite skinbooster can be used as a dermal filler. It can be used to add volume and remodelling or Juvederm Volite can be used as a stand alone treatment especially good for our younger patients or if you simply want glowing skin. I find it useful for fine lines for example, skin lines, esp when used together with microbotox. Below is an example.

How effective is Volite skinboosters?

As mentioned, Volite delivers improvements in skin quality including smoothness (absence of fine lines), hydration and elasticity. In clinical studies, results were sustained at six months, where patients reported that they continued to see significant improvements in skin hydration and were satisfied with their skin.

I find the glow and skin hydration from Juvederm Volite improvement superior to majority of skinboosters in the market. I also find the duration superior.

In the past, i stuck strictly to Rejuran Healer PDRN. I was awaiting more evidence and I like to stick to tried and tested, time honoured products. I have to say, I think Profhilo is really badass good. Now, theres Nucleofill PDRN, a higher molecular weight PDRN that has a role to contribute in skin rejuvenation. And with Juvederm Volite, we have a skinbooster treatment that lasts 9 months.

What is profhilo? | 逆时针

It is a new technology that biologically remodels your skin.
Neither a filler nor skin booster, Profhilo® is a patented technology of bio-remodeling injectable.
In my clinical experience,

In my clinical experience, I find that Skinboosters 水光针| Hydroboosters | Babyboosters are perfect for hydrating our skin. We need a series of 3 – 4 sessions. Cost is cheapest. Product consists of hyluronic acid, compatible with your skin.

Nucleofill, Rejuran 婴儿针, via PDRN technology, helps renew your skin and is perfect for skin remodelling, hence pore tightening and improving skin laxity. We need a series of 3 – 4 sessions.

The key benefit of Profhilo, is its ability to remodel skin and improve skin laxity. We need a series of 2 sessions minimum, and cost is an issue. But in experienced hands and at reasonable price, do the results justify the cost? Lets investigate. 

What is the difference between Gouri and Profhilo?

The difference lies in the ingredients. Gouri contains PLLA which stimulates collagen gradually for skin tightening and brightening. Profhilo contains hyaluronic acid for immediate skin hydration and tightening.

How does Profhilo work?

Is Profhilo better than Botox?

The 2 are complementary. Botox works to reduce dynamic lines. Profhilo improves overall skin complexion and helps with static lines.

Profhilo® can bio-stimulate
4 types of collagen | elastin | proliferate adipocytes (fat) stem cells

How long does Profhilo last?

Profhilo generally lasts 6 months if 2 treatments are given one month apart. After the initial treatments, we recommend coming back to see us every 6-9 months. Then only one syringe is needed, as we will be simply topping up the skin’s hydration and glow.

Is Profhilo worth doing?

Is profhilo worth it? Given its price tag, is it really worth it, though? The simple answer is, yes it is. It is quick, effective, less painful with 5 point injection, and does not carry the same risks as other procedures. It provides you with young, healthy, glowy, dewey, fresher looking skin.

How quickly does Profhilo work?

You will start seeing results 4 weeks after 1st treatment. Best results in 8 weeks after 1st session. 

Why is Profhilo so popular?

As you grow older, your skin’s hyaluronic acid levels dip. Hyaluronic acid is one of the things that keep skin looking plumped up and hydrated,

There are a number of brands of injectable moisturiser out there, but Profhilo is the one that has caught people’s imagination. It’s not a filler, it doesn’t add volume to the face, but it improves the skin health and strength.

BONUS: Profhilo requires far fewer injections than some other products, so less pain, less downtime, less bruising.

Profhilo works from the inside, boosting hydration and encouraging bioremodelling of your collagen and elastin fibres.

Older skin is characterised by loss of and abnormalities in Hyaluronic acid, collagen and elastin.

In this way, Profhilo is designed to improve the levels and quality of the three biological factors, keeping your skin looking fresh, plump and youthful
Is Profhilo better than a filler?

Profhilo is not a dermal filler. It works by remodelling skin, so its more than your typical skinbooster. It has anti-ageing and skin firming properties. Works very naturally and skin quality changes are visible in majority of cases.

Is there any pain or downtime in the treatment?

With just 5 injections per side, the downtime is minimal, with less pain, less swelling, less bruising.
The Hyaluronic Acid diffuses across the widest sections of your face through subdermal patterns, stimulating the production of elastin, collagen and hydration in the skin.

Is Profhilo dangerous?

How many sessions of Profhilo would I need?

In majority of cases, at least 2 sessions*, spaced 1 month apart, Profhilo® can last between 6 – 12 months.

Profhilo is FDA approved for anti ageing. In some cases, you may experience side effects are redness, soreness and bruising. 

How does skin remodelling help you?

According to the manufacturer, this technology can

1. Reverse ageing
2. combat skin laxity and signs of skin aging
3. boost and hydrate your skin

Is Profhilo safe on human skin?

It is a 100% pure hyaluronic acid compound, completely biocompatible with skin, so it doesn’t harm skin tissue in any way. According to the manufacturer: During clinical testing, Profhilo® showed no negative side-effects.

How often would I need Profhilo?

The current recommendation is yearly.

Can Profhilo be combined with other products?

Profhilo® delivers great results as a treatment on its own or in combination with other aesthetics treatments. And yes, I like to combine it to give my patients optimum results with minimal pain and downtime.

What is Nucleofill?

Nucleofill is a relatively new bio-stimulator for skin rejuvenation and protection. As an anti-ageing treatment, it is designed to help cells retain water, improve skin elasticity and tightness, and aid in the prevention of wrinkles.

What is the difference between Nucleofill and Profhilo? | Which is right for you? Is Nucleofill a filler?

Nucleofill is strictly not a filler. It consists of high molecular weight PDRN, derived from Salmon DNA. This treatment is safe on all skin types. This treatment can be done in combination with other treatments.

So what is Rejuran healer treatment?

What is PDRN treatment?

What is nucleofill skin treatment?

This is the use of highly bio-compatible DNA fragments (Polynucleotides), derived from Salmon DNA, to improve the overall condition of your skin. It helps to repair skin, reduce inflammation and reduce ischemia.

Are the effects of Rejuran healer, PDRN, nucleofill permanent?

Is Rejuran, Nucleofill permanent?

Collagen-stimulating treatments such as rejuran, nucleofill, sculptra are effective for rolling scars. They produce semi-permanent effects. The result of these new collagen stimulated lasts in line with your skin’s natural ageing.

How long can Rejuran Healer, Nucleofill last?

The duration depends on many factors, such patient, physician and product factors. Examples include physician technique, individual skin condition, choice of filler product, area treated. In expert hands, the effects typically lasts between 6-12 months.

What can PDRN, Rejuran healer, nucleofill help with?

• •       1. Rejuvenation of midface
• •       2. Rejuvenation of full face
• •       3. Rejuvenation of Neck lines
• •       4. Atrophic scars | acne scars | Inflammatory acne
• •       5. Dark eye circle, Undereye rejuvenation |

What is nucleofill and how does it help aging?

1. Its main indication is the treatment of facial aging as it reverses the effects of skin laxity associated with age.
2. ✓ Bioremodelation: with the concentration of Nucleofill 2% we have the possibility of
3. intervening on skin laxity.
4. ✓ Bioregenerating the dermis and stimulating the synthesis of collagen and elastin. This will
5. stimulate the fibroblast and achieve a neoformation of the dermal matrix, as well as a
6. restructuring thereof – thanks to the formation of type I collagen.
7. ✓ Hydrolifting: hydrating and stimulating the production of endogenous hyaluronic acid.
8. ✓ Support in the mechanical remodeling of the dermis.

1. Nucleofill has beneficial properties at different levels:
2. ✓ Increased synthesis of collagen in keratinocytes;
3. ✓ Increase in elastin synthesis (by fibroblasts and keratinocytes);
4. ✓ Increase in fibroblast synthesis;
5. ✓ Feeding of the dermis cells;
6. ✓ Improvement of the elasticity of the skin;
7. ✓ Less inflammatory response;
8. ✓ Prolonged action over time.

Conclusion: Is Profhilo better than Rejuran and nucleofill?

Safety wise, it is FDA approved.

Efficacy wise, there are clinical papers supporting it, but pretty low powered papers. I would say all have value in your skin rejuvenation journey.

Price wise, it is way more expensive. Rejuran is at $799 per 2ML syringe, Skinboosters at $699 per 1ML, Profhilo starts from 1k per 2ml. Nucleofill starts @800 per syringe.

Previously, I mentioned I will be sticking to rejuran for now, until better studies are out. I have had very good experience with Rejuran for skin tone and textural improvement and as the saying goes, if it aint broken, dont fix it. || Now I say, Profhilo is bad-ass good. And I will recommend it for certain groups of patients, together with Nucleofill for optimum results ✅
– Dr Daniel Chang

1) Stellavato A. et al. 2016; PLoS One 11(10):e0163510. 

2) Stellavato A. et al. 2017 Cell Physiol Biochem 2017; 44:1078-1092. 

3) Profhilo leaflet. 

4) D’Agostino A. et al. 2015; BMC Cell Biol 16:19. 

5) Sundaram H. et al. 2016;  Poster Presentation, American Society for Dermatologic Surgery (ASDS) Annual Meeting. 

6) Sparavigna A. et al. 2016; Clin Cosmet Investig Dermatol 9:297-305. 

7) Laurino C. et al. 2015; Eplasty 15:e46. 

8) Rodríguez Abascal M et al. 2015; Eur Aesth Plast Surg J 2015; 5(2): 124-131. 

9) Beatini A. et al. 2016; Aesthetic Medicine 2(2):45-51  

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